Metabolism of Thiamine Triphosphate in Rat Brain: Correlation with Chloride Permeability
نویسندگان
چکیده
منابع مشابه
Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain.
In animals, thiamine deficiency leads to specific brain lesions, generally attributed to decreased levels of thiamine diphosphate, an essential cofactor in brain energy metabolism. However, another far less abundant derivative, thiamine triphosphate (ThTP), may also have a neuronal function. Here, we show that in the rat brain, ThTP is essentially present and synthesized in mitochondria. In mit...
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متن کاملSYNTHESIS OF 1,8-DIOXO-OCTAHYDROXANTHENES WITH THIAMINE CHLORIDE IN ECO-FRINDLY AND SOLVENT FREE CONDITION
A novel, simple and environmentally friendly method is reported for the preparation of 1,8-dioxo-octahydroxanthene derivatives by the reaction of dimedon with various aromatic aldehydes, using thiamine chloride as a recyclable catalyst under solvent-free conditions. This procedure has following benefits; simple workup, moderate reaction times, good yields, and completely compatible with enviro...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 1993
ISSN: 0022-3042,1471-4159
DOI: 10.1111/j.1471-4159.1993.tb03168.x